Photo: Dylan Gillis


Say aloud your digital design worries!

Choose the discussion channel according to your own department.

You can use Finnish or English here.

Forum Navigation

Does Malegra DXT interact with other medications?


Malegra DXT is a combination medication that contains two active ingredients: sildenafil (a PDE5 inhibitor) and duloxetine (a serotonin-norepinephrine reuptake inhibitor, or SNRI). As with any medication, Malegra DXT has the potential to interact with other drugs, which may affect its safety, efficacy, or both. Some potential interactions to be aware of include:

Nitrates: Sildenafil, the active ingredient in Malegra DXT can potentiate the effects of nitrates, which are commonly used to treat chest pain (angina) and certain heart conditions. Combining Malegra DXT with nitrates can lead to a dangerous drop in blood pressure, which may result in fainting, dizziness, or even life-threatening complications. Therefore, it's crucial to avoid taking Malegra DXT concurrently with nitrates.

Other medications that affect serotonin levels: Duloxetine, the other active ingredient in Malegra DXT, is an SNRI that increases serotonin levels in the brain. Combining Malegra DXT with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, or certain migraine medications, may increase the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition characterized by symptoms such as agitation, hallucinations, rapid heartbeat, fever, sweating, tremors, and loss of coordination.

Monoamine oxidase inhibitors (MAOIs): MAOIs are a class of antidepressants that can interact with duloxetine and increase the risk of serotonin syndrome. Therefore, it's essential to avoid combining Malegra DXT with MAOIs or within two weeks of discontinuing MAOI therapy.

Alpha-blockers: Alpha-blockers are medications used to treat high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). When used concurrently with sildenafil, the PDE5 inhibitor in Malegra DXT, alpha-blockers can potentiate the blood pressure-lowering effects of both drugs, leading to symptomatic hypotension (low blood pressure) and related side effects such as dizziness, lightheadedness, and fainting.

Other medications metabolized by the liver: Both sildenafil and duloxetine are metabolized by enzymes in the liver, particularly the CYP3A4 enzyme system for sildenafil and the CYP1A2 and CYP2D6 enzyme systems for duloxetine. Therefore, medications that inhibit or induce these enzymes may affect the metabolism and clearance of sildenafil and duloxetine, potentially altering their blood levels and increasing the risk of side effects or toxicity.

It's essential to inform your healthcare provider about all medications (including prescription, over-the-counter, herbal supplements, and recreational drugs) you are taking before starting treatment with Malegra DXT. Your healthcare provider can evaluate potential drug interactions and adjust your treatment plan accordingly to ensure safe and effective use of Malegra DXT.




Last Updated on 4.8.2021